Perplexing bodies: The putative roles of P-bodies in neurons
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چکیده
منابع مشابه
P-bodies and stress granules: possible roles in the control of translation and mRNA degradation.
The control of translation and mRNA degradation is important in the regulation of eukaryotic gene expression. In general, translation and steps in the major pathway of mRNA decay are in competition with each other. mRNAs that are not engaged in translation can aggregate into cytoplasmic mRNP granules referred to as processing bodies (P-bodies) and stress granules, which are related to mRNP part...
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For many years studies on the regulation of gene expression have focused on the control of transcription, thinking that once the gene was expressed as mRNA it would be translated and when its time was up it would simply be degraded in the cytoplasm. However, recent years have seen increasing interest in mechanisms involved in the post-transcriptional regulation of gene expression. An important ...
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The dendritic localization of mRNAs and their subsequent translation at stimulated synapses contributes to the experience-dependent remodeling of synapses and thereby to the establishment of long-term memory. Localized mRNAs are transported in a translationally silent manner to distal dendrites in specific ribonucleoprotein particles (RNPs), termed transport RNPs. A recent study suggested that ...
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Egg P bodies protect maternal mRNA P bodies (processing bodies) are cytoplasmic granules that, in somatic cells, store and degrade mRNAs. But P bodies in the worm egg protect mRNA, according to a study by Boag et al. In a separate study Noble et al. observed that worm eggs have different fl avors of P bodies depending on developmental stage. Boag et al. showed that P bodies in eggs lack an mRNA...
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ژورنال
عنوان ژورنال: RNA Biology
سال: 2008
ISSN: 1547-6286,1555-8584
DOI: 10.4161/rna.6948